Asian Journal of Transfusion Science
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CASE REPORT
Year : 2008  |  Volume : 2  |  Issue : 2  |  Page : 81-83

Anti-M: Report of two cases and review of literature


Department of Transfusion Medicine, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Rae Bareily Road, Lucknow, Uttar Pradesh, India

Correspondence Address:
Rajendra Chaudhry
Department of Transfusion Medicine, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Rae Bareily Road, Lucknow, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-6247.42695

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Anti-M is a fairly common naturally occurring antibody with rarely causing hemolytic transfusion reactions or hemolytic disease of the newborn. Most anti-M are not active at 37 o C and can generally be ignored in transfusion practice. However, we did not find this antibody to be fairly common and detected only two cases of anti-M in the past three years. We describe these two cases; one 'immunizing' type and other 'naturally occurring' and review the literature. The immunizing type was reactive at 37 o C as well as AHG phase of testing with IgG component, and showing dosage effect while the other was 'naturally occurring' reactive well below 37 o C. Though rare, sometimes these antibodies can be of clinical significance when the antibody detected is reactive at 37 o C and AHG phase. When the antibody is active at 37 o C, M antigen negative cross match compatible red cell unit should be given.


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2006 - Asian Journal of Transfusion Science | Published by Wolters Kluwer - Medknow
Online since 10th November, 2006