Asian Journal of Transfusion Science
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ORIGINAL ARTICLE
Year : 2010  |  Volume : 4  |  Issue : 1  |  Page : 31-33

Prevalence of glucose-6-phosphate dehydrogenase deficiency and sickle cell trait among blood donors in Riyadh


1 Department of Pathology and Laboratory Medicine, Haematology Unit, King Khalid University Hospital, Riyadh, Saudi Arabia
2 Department of Pathology and Laboratory Medicine, Blood Bank, King Khalid University Hospital, Riyadh, Saudi Arabia

Correspondence Address:
Mohammed K Alabdulaali
PO Box 1, Postal Code-31982, Hassa
Saudi Arabia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-6247.59389

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Background and Aims: Blood donation from glucose-6-phosphate dehydrogenase (G6PD)-deficient and sickle cell trait (SCT) donors might alter the quality of the donated blood during processing, storage or in the recipient's circulatory system. The aim of this study was to determine the prevalence of G6PD deficiency and SCT among blood donors coming to King Khalid University Hospital (KKUH) in Riyadh. It was also reviewed the benefits and risks of transfusing blood from these blood donors. Materials and Methods: This cross-sectional study was conducted on 1150 blood samples obtained from blood donors that presented to KKUH blood bank during the period April 2006 to May 2006. All samples were tested for Hb-S by solubility test, alkaline gel electrophoresis; and for G6PD deficiency, by fluorescent spot test. Results: Out of the 1150 donors, 23 (2%) were diagnosed for SCT, 9 (0.78%) for G6PD deficiency and 4 (0.35%) for both conditions. Our prevalence of SCT and G6PD deficiency is higher than that of the general population of Riyadh. Conclusion: We recommend to screen all units for G6PD deficiency and sickle cell trait and to defer donations from donors with either of these conditions, unless if needed for special blood group compatibility, platelet apheresis or if these are likely to affect the blood bank inventory. If such blood is to be used, special precautions need to be undertaken to avoid complications in high-risk recipients.


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2006 - Asian Journal of Transfusion Science | Published by Wolters Kluwer - Medknow
Online since 10th November, 2006