Asian Journal of Transfusion Science
Home About Journal Editorial Board Search Current Issue Ahead of print Back Issues Instructions Subscribe Login  Users: 1385 Print this page  Email this page Small font sizeDefault font sizeIncrease font size 


 
LETTER TO THE EDITOR Table of Contents   
Year : 2010  |  Volume : 4  |  Issue : 1  |  Page : 41-42
Infectious disease markers in blood donors at central referral hospital, Gangtok, Sikkim


1 Department of Microbiology, Sikkim-Manipal Institute of Medical Sciences (SMIMS) and Central Referral Hospital (CRH), 5th Mile Tadong, Gangtok, Sikkim - 737 102, India
2 Department of Medical Microbiology, Sikkim-Manipal Institute of Medical Sciences (SMIMS) and Central Referral Hospital (CRH), 5th Mile Tadong, Gangtok, Sikkim - 737 102, India
3 Department of Pathology, Sikkim-Manipal Institute of Medical Sciences (SMIMS) and Central Referral Hospital (CRH), 5th Mile Tadong, Gangtok, Sikkim - 737 102, India
4 Department of Community Medicine, Sikkim-Manipal Institute of Medical Sciences (SMIMS) and Central Referral Hospital (CRH), 5th Mile Tadong, Gangtok, Sikkim - 737 102, India

Click here for correspondence address and email

Date of Web Publication25-Jan-2010
 

How to cite this article:
Adhikari L, Bhatta D, Tsering DC, Sharma DK, Pal R, Gupta A. Infectious disease markers in blood donors at central referral hospital, Gangtok, Sikkim. Asian J Transfus Sci 2010;4:41-2

How to cite this URL:
Adhikari L, Bhatta D, Tsering DC, Sharma DK, Pal R, Gupta A. Infectious disease markers in blood donors at central referral hospital, Gangtok, Sikkim. Asian J Transfus Sci [serial online] 2010 [cited 2019 Oct 20];4:41-2. Available from: http://www.ajts.org/text.asp?2010/4/1/41/59392


Sir,

A safe blood is a critical component in improving health care and in preventing the spread of infectious diseases globally. Yet the quality and safety of blood transfusion is still a concern for a health-care personnel.

The extent of infectious disease markers of major blood-borne pathogens [hepatitis B (HBV), hepatitis C (HCV), human immunodeficiency virus (HIV), syphilis and malarial parasite] was observed as with age and sex distribution for the donor population of the blood bank of a tertiary care hospital of Gangtok during 2001-2008.

Of the 3735 donors, 2423 (64.87%) were replacement and 1312 (35.13%) voluntary donors; male donors were 3434 (91.94%) and females were 301 (8.06%) with overall seroprevalence of major blood-borne pathogens (HIV, HBV, HCV and Syphilis) was 1.63%. The sero-positivity of HIV, HBsAg, anti- HCV, and syphilis was 0.32, 0.78, 0.27 and 0.27%, respectively. Unlike other studies, [1],[2] which showed a lower prevalence of HIV, HBsAg, and anti-HCV in voluntary donors, we observed a higher HIV, HBsAg, and anti-HCV sero- positivity in voluntary donors as compared to replacement donors, though the difference in prevalence in these two groups was not statistically significant [Chi-square test (with Yates correction) = 0.02974 (P = 0.10); 0.01495; (P = 0.9027); 1.738 (P = 0.1874) respectively]. Whereas syphilis positivity was found to be higher in replacement donors as compared to voluntary donors though not statistically significant [Chi-square test (with Yates correction) = 0.4513 (P = 0.5017)], which was in agreement with other studies. [1],[2] HIV and anti-HCV sero-positivity was nil from 2001 to 2005 among our donors. There was no significant change in the prevalence of HIV, HBsAg, HCV, and syphilis positivity over the period (Chi - square for trend = 5.913, P = 0.0120; 0.01728, P = 0.6776; 2.440, P = 0.1183; 0.04003, P = 0.8414, respectively).

There was no HIV, HCV and syphilis positive case among female donors in our study population. The HBV positivity was the only infection found in one female donor in our total female donors in the age group of 21-40, which was statistically significant (P = 0.0062). There were no HIV and syphilis positive cases below the age of 21 years. No sample showed malarial parasites. There was not a single case positive for co-infection with two or more infectious agents.

Though the screening tests used for these infections were not 100% sensitive or specific, [3],[4] and the approximation of the infectious disease markers in our donor population was less, there is no scope of complacency.

 
   References Top

1.Gupta N, Kumar V, Kaur A. Seroprevalence of HIV, HBV,HCV and syphilis in voluntary blood donors. Indian J Med Sci 2004;58:255-7.   Back to cited text no. 1  [PUBMED]  Medknow Journal  
2.Singh B, Kataria SP, Gupta R. Infectious markers in blood donors of East Delhi: Prevalence and trends. Indian J Pathol Microbiol 2004;47:477-9.  Back to cited text no. 2      
3.Viswanathan C. Are our donors safe? Indian J Pediatr 2001;68:69-75.  Back to cited text no. 3  [PUBMED]  [FULLTEXT]  
4.Stramer SL, Glynn SA, Kleinman SH, Strong DM, Caglioti S, Wright DJ, et al . Detection of HIV-1 and HCV Infections among Antibody-Negative Blood Donors by Nucleic Acid-Amplification Testing. New Eng J Med 2004; 351:760-68.  Back to cited text no. 4      

Top
Correspondence Address:
Luna Adhikari
Department of Microbiology, Sikkim-Manipal Institute of Medical Sciences (SMIMS) and Central Referral Hospital (CRH), 5th Mile Tadong, Gangtok, Sikkim - 737 102
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-6247.59392

Rights and Permissions



This article has been cited by
1 Transfusion transmissible infections among blood donors from asub-Himalayan rural tertiary care centre in Darjeeling, India
Rupali Mandal,Krishnendu Mondal
Journal of Traditional and Complementary Medicine. 2015;
[Pubmed] | [DOI]
2 Consensus Statement of HCV Task force of the Indian National Association for Study of the Liver (INASL). Part I: Status Report of HCV Infection in India
Pankaj Puri,Anil C. Anand,Vivek A. Saraswat,Subrat K. Acharya,Radha K. Dhiman,Rakesh Aggarwal,Shivram P. Singh,Deepak Amarapurkar,Anil Arora,Mohinish Chhabra,Kamal Chetri,Gourdas Choudhuri,Vinod K. Dixit,Ajay Duseja,A.K. Jain,Dharmesh Kapoorz,Premashis Kar,Abraham Koshy,Ashish Kumar,Kaushal Madan,Sri P. Misra,Mohan V.G. Prasad,Aabha Nagral,Amarendra S. Puri,R. Jeyamani,Sanjiv Saigal,Shiv K. Sarin,Samir Shah,P.K. Sharma,Ajit Sood,Sandeep Thareja,Manav Wadhawan
Journal of Clinical and Experimental Hepatology. 2014;
[Pubmed] | [DOI]
3 Prevalence of markers of Hepatitis C virus among the blood donors
Kaur, H. and Manjari, M. and Thaman, R.G. and Singh, G.
Journal of Clinical and Diagnostic Research. 2012; 6(6): 959-962
[Pubmed]
4 Family/friend donors are not true voluntary donors
Jain, R. and Gupta, G.
Asian Journal of Transfusion Science. 2012; 6(1): 29-31
[Pubmed]



 

Top
 
  Search

  
  
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Email Alert *
    Add to My List *
* Registration required (free)  


    References

 Article Access Statistics
    Viewed2601    
    Printed146    
    Emailed1    
    PDF Downloaded112    
    Comments [Add]    
    Cited by others 4    

Recommend this journal

Association Contact us | Sitemap | Advertise | What's New | Feedback | Copyright and Disclaimer

2006 - Asian Journal of Transfusion Science | Published by Wolters Kluwer - Medknow
Online since 10th November, 2006