Asian Journal of Transfusion Science
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ORIGINAL ARTICLE
Year : 2015  |  Volume : 9  |  Issue : 1  |  Page : 48-54

Molecular basis of Rh blood group system in the Malaysian population


1 Regenerative Medicine Cluster, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Pulau Penang; Immunohematology Division, National Blood Center, Institute for Medical Research, Kuala Lumpur, Malaysia
2 Medical Research Resource Centre, Institute for Medical Research, Kuala Lumpur, Malaysia
3 Immunohematology Division, National Blood Center, Institute for Medical Research, Kuala Lumpur, Malaysia
4 Regenerative Medicine Cluster, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Pulau Penang, Malaysia

Correspondence Address:
Rozi Hanisa Musa
National Blood Center, Jalan Tun Razak, 50400 Kuala Lumpur
Malaysia
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Source of Support: The work was funded by the Postgraduate Studentsí Fund, AMDI, USM, Conflict of Interest: None


DOI: 10.4103/0973-6247.150951

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Background: Rh molecular studies have been previously mainly conducted in Caucasians and African population. There is a limited data on the molecular basis for Rh genotypes among Asians. Aims: This study aims to characterize the Rh genes and frequency of the various RH genotypes among blood donors in National Blood Centre (NBC), Kuala Lumpur. Materials and Methods: A total of 1014 blood samples were obtained from blood donors from four different ethnic groups (360 Malays, 434 Chinese, 164 Indians and 56 others). Serological and molecular analysis of all 1014 blood samples were performed. An automated deoxyribonucleic acid sequencing analysis was performed. Results: Rh phenotypes and RH genotypes showed heterogeneity and significant association with ethnicities. Discrepancies in allele D, C/c and E/e between phenotypes and genotypes results were observed. Discrepancy results in allele D showed significant association with the ethnic groups of the blood donors in NBC. There were multiple novel mutations (23) and published mutations (5) found in this study. Significant associations between discrepancy results and mutations were found in allele D and C/c. Conclusion: Performing RH molecular analysis in Malaysian population provided the basic database for the distribution of Rh genotypes of donors from major ethnic groups in Malaysia.


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