Asian Journal of Transfusion Science
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LETTER TO THE EDITOR Table of Contents   
Year : 2017  |  Volume : 11  |  Issue : 1  |  Page : 69-70
Should we reconsider platelet content criteria for single donor platelets in West Bengal, India?


Department of Transfusion Medicine, TATA Medical Center, Kolkata, West Bengal, India

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Date of Web Publication22-Feb-2017
 

How to cite this article:
Javed R, Basu S. Should we reconsider platelet content criteria for single donor platelets in West Bengal, India?. Asian J Transfus Sci 2017;11:69-70

How to cite this URL:
Javed R, Basu S. Should we reconsider platelet content criteria for single donor platelets in West Bengal, India?. Asian J Transfus Sci [serial online] 2017 [cited 2017 Sep 19];11:69-70. Available from: http://www.ajts.org/text.asp?2017/11/1/69/200771


Sir,

As a tertiary oncology center in Eastern India, we cater to transfusion needs of a large number of patients from the Eastern region and neighboring countries. As part of quality control (QC), NABH and AABB have specified a minimum platelet content of 3 × 1011 in single donor platelet (SDP) concentrates. A lower mean platelet count is reported in West Bengal native donors and could potentially result in lower platelet yield in SDP donations.[1]

We examined platelet yield in SDP products from volunteer West Bengal native donors. We retrospectively analyzed SDP collections at our transfusion medicine unit over 7 months from January 1, 2015, to July 31, 2015. SDP collections were performed using the MCS+ 9000 system from Haemonetics, USA. The collection efficiency of the equipment ranged from 56% to 60%. Product platelet counts were assessed using the Coulter Ac Tdiff2 instrument (Beckman Coulter). Donors free of transfusion-transmitted infections, hemoglobin between 12.5 and 18 g/dl, and having a minimum platelet count of 1.5 lakhs/cumm were taken up for donations.

We identified two categories of SDP donors; Category A: West Bengal native donors (West Bengal residents with Bengali as mother tongue) and Category B: non-native donors. A total of 311 donors were screened, and 252 procedures were performed. QC data were available in 182 SDP donations (72% of donations). SDP collections from Category A donors had significantly lower platelet content as compared with Category B donors (Chi-square statistical test, P < 0.05). Based on existing QC specifications, 70.5% of SDP collections from Category A donors were deemed unsatisfactory [Table 1]. Relatively, lower mean platelet counts are reported in West Bengal natives. Constitutional macrothrombocytopenia has also been reported in this region [2],[3] [Table 2].
Table 1: Distribution of donors in our study

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Table 2: Comparison of different studies

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Roy et al. reported that SDPs from donors with giant platelets led to better platelet recovery in patients and suggested that donors with giant platelets should be eligible for SDP donations.[4] The current QC criteria for SDP products are too stringent for donors from Eastern India and exclude a significant proportion of otherwise suitable volunteer SDP donors. We call for a review of QC criteria for SDP donations from native donors and suggest that this can be linked to the analysis of platelet recovery in transfused patients.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.[5]

 
   References Top

1.
Cines DB, Bussel JB, McMillan RB, Zehnder JL. Congenital and acquired thrombocytopenia. ASH Educ Program Book 2004;2004:390-406.  Back to cited text no. 1
    
2.
Naina HV, Nair SC, Harris S, Woodfield G, Rees MI. Harris syndrome – A geographic perspective. J Thromb Haemost 2005;3:2581-2.  Back to cited text no. 2
    
3.
Naina HV, Nair SC, Daniel D, George B, Chandy M. Asymptomatic constitutional macrothrombocytopenia among West Bengal blood donors. Am J Med 2002;112:742-3.  Back to cited text no. 3
    
4.
Roy AD, Choudhury N, Ray D. Giant platelets in platelet donors – A blessing in disguise? J Clin Diagn Res 2015;9:EC01-3.  Back to cited text no. 4
    
5.
Choccalingam C, Samuel P, Swamynathan K. Harris platelet syndrome: The need to recognise the entity. J Med Health Sci 2013;4:11-2.  Back to cited text no. 5
    

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Correspondence Address:
Rizwan Javed
14 MAR (E-W), New Town, Rajarhat, Kolkata - 700 156, West Bengal
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-6247.200771

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  [Table 1], [Table 2]



 

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2006 - Asian Journal of Transfusion Science | Published by Wolters Kluwer - Medknow
Online since 10th November, 2006