Asian Journal of Transfusion Science
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ORIGINAL ARTICLE
Year : 2010  |  Volume : 4  |  Issue : 2  |  Page : 99-101

Clinical and cytogenetic analysis of human anemias from Jammu region of Jammu and Kashmir state


1 Institute of Human Genetics, University of Jammu, Jammu- 180006, India
2 Department of Blood Transfusion & Immunohaematology Med., Govt. Medical College, Jammu, India
3 Department of Zoology, University of Jammu, Jammu-180006, India

Correspondence Address:
Subash Gupta
Centre Coordinator, Institute of Human Genetics, University of Jammu, Jammu-180006
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-6247.67031

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Background : Anemias are the blood disorders characterized by reduction in the number of circulating red blood cells, the amount of hemoglobin, or the volume of packed red cells in blood. Chromosomal aberrations have often been reported from the bone marrow as well as cultured lymphocytes of the anemic patients. Aims: The aims of the study were to find out the commonest type of anemia occurring in the population of Jammu, India and to find out the chromosomal changes involved in the disorder. Material and Methods: Present study has been carried out on the bone marrow samples from 53 clinically diagnosed anemic patients. Cytogenetic study was carried out on slides prepared from these samples. Noncytogenetic factors like age, sex, religion, blood groups, family history of anemia, socioeconomic status, etc. have also been included in the study. Results: Megaloblastic anemia was found to be the commonest type of anemia. Centromere stretching, chromatid breaks, gaps, and elongation of chromosomes were recorded in patients with megaloblastic anemia and combined deficiency anemia. However, structural changes and numerical changes were totally absent. Conclusion: The commonest anemia among the people of Jammu region is megaloblastic anemia and its prevalence is increasing every year. Also, megaloblastic anemia is always associated with reversible cytogenetic changes.


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2006 - Asian Journal of Transfusion Science | Published by Wolters Kluwer - Medknow
Online since 10th November, 2006