Asian Journal of Transfusion Science
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ORIGINAL ARTICLE
Year : 2011  |  Volume : 5  |  Issue : 2  |  Page : 127-131

Study of the effect of iron overload on the function of endocrine glands in male thalassemia patients


1 Department of Internal Medicine, College of Medicine, Al-Kufa University, Iraq
2 Department of Chemistry, College of Science, Al-Kufa University, Iraq
3 Department of Chemistry, College of Medicine, Al-Kufa University, Iraq

Correspondence Address:
Hussein Kadhem Al-Hakeim
Department of Chemistry, College of Science, Al-Kufa University
Iraq
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-6247.83236

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Background: Iron overload is an important issue in the state of thalassemic patients due to the harmful effect of high concentration of iron deposited in different tissues in human body including endocrine glands. In the present work, an attempt is carried out to estimate the effect of iron overload in thalassemic patients on the function of endocrine glands through the estimation of their ability to secrete adequate amounts of certain hormones. Materials and Methods: Seventy eight male children with beta-thalassemia, in the age-group of 4-11 years, were enrolled for this research. These children were being treated with frequent transfusions and long-term iron chelation therapy. Thirty age and sex matched children without thalassemia constituted the control group. Ferritin and different hormones were estimated by ELISA technique. Results: The results showed a mild reduction in the function of endocrine glands through the decrease in the level of some hormones. These changes due mainly to the hypoxia and precipitation of iron in certain glands and overlapping with the synthesis or secretion of the hormones. Conclusion: There is a different hormonal disturbances in beta thalassemia patients. Reduction of total body iron store is an important goal of the treatment of thalassemia and measuring the hormones concentration is necessary for the follow up of the thalassemic patients especially during puberty.


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2006 - Asian Journal of Transfusion Science | Published by Wolters Kluwer - Medknow
Online since 10th November, 2006