Asian Journal of Transfusion Science
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LETTER TO THE EDITOR Table of Contents   
Year : 2011  |  Volume : 5  |  Issue : 2  |  Page : 179-180
Re: Heparin-induced thrombocytopenia - Type 2

Ronak Endo-laparoscopy and General Surgical Hospital, Patan, Gujarat, India

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Date of Web Publication28-Jul-2011

How to cite this article:
Yagnik VD. Re: Heparin-induced thrombocytopenia - Type 2. Asian J Transfus Sci 2011;5:179-80

How to cite this URL:
Yagnik VD. Re: Heparin-induced thrombocytopenia - Type 2. Asian J Transfus Sci [serial online] 2011 [cited 2022 Jun 30];5:179-80. Available from:


I read an article entitled "Heparin-induced thrombocytopenia (HIT) - Type 2" [1] with interest. I would like to congratulate author for his effort to concise such a topic in a nice manner. However, I would like to add few more information regarding this entity which you may find useful [Table 1].
Table 1: Features of HIT

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Pretest probability is calculated on the basis of 4Ts: Thrombocytopenia, timing of thrombocytopenia, thrombosis, other cause of thrombocytopenia. Probability is high if more than 50% drop in platelet count after 5 days of initiation of heparin and new development of thrombosis with no other cause for thrombocytopenia.

I would like to summarize the treatment for HIT: Stop heparin, postpone warfarin until substantial recovery in platelet count, avoid platelet transfusions, [3] start alternative anticoagulants like lepirudin and argatroban (direct thrombin inhibitor), danaparoid, or fondaparinux (factor Xa inhibitor).

Fondaparinux is a synthetic heparin pentasaccharide which does not cross-react with HIT antibodies and can be used for the treatment of HIT. [4]

   References Top

1.Majeed TA. Heparin induced thrombocytopenia-type 2. Asian J Transfus Sci 2010;4:137.  Back to cited text no. 1
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2.Warkentin TE, Levine MN, Hirsh J, Horsewood P, Roberts RS, Gent M, et al. Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin. N Engl J Med 1995;332:1330-5.  Back to cited text no. 2
3.Warkentin TE. Heparin-induced thrombocytopenia: Diagnosis and management. Circulation 2004;110:e454-8.  Back to cited text no. 3
4.Kuo KH, Kovacs MJ. Successful treatment of heparin induced thrombocytopenia (HIT) with fondaparinux. Thromb Haemost 2005;93 : 999-100.  Back to cited text no. 4

Correspondence Address:
Vipul D Yagnik
77, Siddhraj Nagar, Rajmahal Road, Patan - 384 265, Gujarat
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-6247.83254

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  [Table 1]



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2006 - Asian Journal of Transfusion Science | Published by Wolters Kluwer - Medknow
Online since 10th November, 2006