Asian Journal of Transfusion Science
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ORIGINAL ARTICLE
Year : 2013  |  Volume : 7  |  Issue : 1  |  Page : 42-47

Increased preoperative collection of autologous blood with recombinant human erythropoietin therapy in tertiary care hospitals of Jammu


1 Department of Transfusion Medicine, Acharya Shri Chander College of Medical Sciences and Hospital, Sidhra, Jammu, India
2 Department of Orthopedics, Duchess of Kent, Hospital, Hong Kong
3 Department of Interventional Cardiology, Mount Sinai Hospital, New York, USA
4 Department of Orthopedics, Acharya Shri Chander College of Medical Sciences and Hospital, Sidhra, Jammu, India

Correspondence Address:
Kumkum Sharma
Department of Transfusion Medicine, Acharya Shri Chander College of Medical Sciences and Hospital, Sidhra, Jammu - 180 017, India

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-6247.106733

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Introduction: To study whether the administration of recombinant human erythropoietin increases the amount of autologous blood that can be collected before orthopaedic surgery. Materials and Methods: We conducted a randomized controlled trial of recombinant human erythropoietin in 68 adults scheduled for elective orthopedic procedures. The patients received either erythropoietin 600 units/kg of body weight or placebo intravenously every 5 th day prior to each phlebotomy for 21 days during which time up to 5 units of blood was collected. Patients were excluded from donation when their hematocrit values were less than 33%. All patients received iron sulphate 325mg orally 3 times daily. The mean number of units collected per patient was 4.33 ± 0.4 for erythropoietin group and 3.05± 0.71 for the placebo group. Results: The mean packed red cell volume donated by patients who received erythropoietin was 32% greater than that donated by patients who received placebo (196.3 vs. 169.4 ml, p<0.05). 68% in the placebo group and 9% of patients treated with erythropoietin were unable to donate ≥4 units. No adverse effects were attributed to erythropoietin. While participating in the study, complications developed in 2 patients one in each group necessitating their removal from the study. Conclusion: We conclude that recombinant human erythropoietin increases the ability of the patients about to undergo elective surgery to donate autologous blood units.


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2006 - Asian Journal of Transfusion Science | Published by Wolters Kluwer - Medknow
Online since 10th November, 2006