| ORIGINAL ARTICLE |
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| Year : 2018 | Volume
: 12
| Issue : 1 | Page : 69-74 |
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Relationship between T2* magnetic resonance imaging-derived liver and heart iron content and serum ferritin levels in transfusion-dependent thalassemic children
Kiran Suthar, Vishnu Kumar Goyal, Pramod Sharma, Bindu Deopa, Pradeep Singh Rathore, Rama Krishan Bishnoi
Department of Pediatrics, Dr S N Medical College, Jodhpur, Rajasthan, India
Correspondence Address:
Vishnu Kumar Goyal
4A2, Chopasni Housing Board, Jodhpur - 342 008, Rajasthan
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/ajts.AJTS_3_17
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Context: T2* magnetic resonance imaging (MRI) is being increasingly used for the assessment of organ iron content in thalassemics, but cost is a major prohibitive factor for repeated measurements. If serum ferritin correlates well with the T2* MRI liver and heart, it will be economical and more simple tool to assess organ iron deposition.
Aims: The aim of this study was to find out the relationship between serum ferritin level and T2* MRI-derived liver and heart iron content in transfusion-dependent thalassemic children
Settings: Thalassemia day-care center of a teaching hospital
Design: This was a cross-sectional study
Subjects And Methods: Seventy-three transfusion-dependent beta thalassemic children belonging to 2–18 years of age were subjected to T2* MRI of heart and liver to assess their iron content. Values obtained here were related to serum ferritin.
Statistical Analysis Used: Keeping the correlation between serum ferritin and T2* MRI as primary outcome, spearman's correlation coefficient was calculated.
Results: We found poor (negative) correlation between serum ferritin level and T2* MRI liver (r = -0.448, P = 0.000) but no correlation between serum ferritin and T2*MRI heart (r = -0.221, P = 0.060).
Conclusions: Serum ferritin cannot reliably predict the liver and heart iron content in Indian children with β thalassemia. |
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