Asian Journal of Transfusion Science
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CASE REPORT
Year : 2020  |  Volume : 14  |  Issue : 2  |  Page : 200-202

Daratumumab: The perplexity in immunohematology with emerging horizons in myeloma therapy


1 Department of Transfusion Medicine and Transplant Immunology, Indraprastha Apollo Hospital, New Delhi, India
2 Department of Internal Medicine, Rutgers Robert Wood Johnson Medical School, Saint Peter's University Hospital, New Brunswick, New Jersey, USA

Correspondence Address:
Dr. Soma Agrawal
Department of Transfusion Medicine and Transplant Immunology, Indraprastha Apollo Hospital, New Delhi - 110 076
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ajts.AJTS_19_19

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CD38 is a disulfide-linked molecule present on red blood cells (RBCs) and daratumumab; an anti-CD38 monoclonal antibody is a novel agent for treating multiple myeloma patients. It also binds to the RBC along with the plasma cells in concern, creating a menace in the immunohematology workups and requires the use of dithiothreitol-treated cells to rule out its interference. Appropriate and timely communication with the clinicians about the patient history goes a long way in solving complex looking immunohematology workups.


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2006 - Asian Journal of Transfusion Science | Published by Wolters Kluwer - Medknow
Online since 10th November, 2006