A case of naturally occurring anti-Dia antibody in a young man

Salfarina Iberahim; Noor Haslina Mohd Noor; Mohd Nazri Hassan; Rosnah Bahar; Shafini Mohdmed Yusoff; Marini Ramli; Wan Suriana Wan Abdul Rahman; Zefarina Zulkafli; Marne Abdullah; Ho Sook Fong; Tengku Muzaffar Tengku Mohamed Shihabudin; Hisham Atan Edinur; Norul Hajar Che Ghazali

doi:10.4103/ajts.ajts_136_21

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CASE REPORT

Year : 2022 | Volume : 16 | Issue : 2 | Page : 276-279

A case of naturally occurring anti-Di^a antibody in a young man

Salfarina Iberahim¹, Noor Haslina Mohd Noor¹, Mohd Nazri Hassan¹, Rosnah Bahar¹, Shafini Mohdmed Yusoff¹, Marini Ramli¹, Wan Suriana Wan Abdul Rahman², Zefarina Zulkafli¹, Marne Abdullah¹, Ho Sook Fong¹, Tengku Muzaffar Tengku Mohamed Shihabudin³, Hisham Atan Edinur⁴, Norul Hajar Che Ghazali⁴
¹ Department of Hematology, School of Medical Sciences, Health Campus; Transfusion Medicine Unit, Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
² School of Dental Sciences, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia
³ Department of Orthopaedic, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia
⁴ School of Health Science, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia

Correspondence Address:
Dr. Noor Haslina Mohd Noor
Associate Professor, Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan
Malaysia

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/ajts.ajts_136_21

The Diego (Di) blood group system comprises 22 antigens located on the band 3 protein, most of which are low-prevalence antigens. The majority of antibodies to Diego system antigens were of clinically insignificant; however anti-Dia, -Dib, -Wra, -ELO and-DISK may cause hemolytic disease of the fetus and newborn (HDFN) and transfusion reaction. We reported a case of naturally occurring of anti-Dia in a young man who presented to our hospital for wound debridement of fingers injury. His serological results were suggestive of anti-Dia antibody, and his molecular blood group showed he has Di (a-b+) antigen. Anti-Dia may be clinically significant. It can cause mild-to-severe HDFN, but there are only infrequent reports of it being clearly implicated in a hemolytic transfusion reaction. We suggest the need for reagent red blood cell panels to include Dia antigen-positive cells in antibody identification tests for our populations.

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