Asian Journal of Transfusion Science

REVIEW ARTICLE
Year
: 2020  |  Volume : 14  |  Issue : 1  |  Page : 4--8

Red blood cell alloimmunization in Iran: A Comprehensive review of the literature


Maryam Sadat Hosseini, Leila Jafari, Reza Shiri Heris, Ahmad Gharehbaghian 
 Department of Laboratory Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Correspondence Address:
Dr. Ahmad Gharehbaghian
Department of Laboratory Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran
Iran

Background: Alloimmunization is an immune response against foreign antigens which introduced into the body through transfusion, pregnancy, or transplantation. This phenomenon is a big challenge in patients, which require regular transfusions. In the current study, we tried to have a comprehensive review on the status of alloimmunization in Iran. For this purpose, we searched for papers investigating alloimmunization in transfusion-dependent patients and also in patients with no regular transfusions who are candidate for surgery or who need blood. Methods: We searched PubMed, Google Scholar, SID, and MAGIRAN databases using the following keywords: “blood transfusion,” “alloimmunization,” “alloantibodies,” “irregular antibodies,” “red cell antibodies,” and “Iran.” No limitation for the date of publication and language of the papers was defined. All the identified records were then screened for the relevance and duplication. Results: A total of 22 papers were included in this study. All of the studies were conducted from 1999 to 2016 and providing alloimmunization data from different cities all over of Iran. In general, the results showed that the most prevalent alloantibodies are anti-Kell (anti-K antigen) and anti-Rh system, mainly anti-E, anti-D, anti-C, and anti-c. Conclusion: Anti-Kell and anti-Rh antibodies are the most prevalent antibodies responsible for alloimmunization in Iranian population.


How to cite this article:
Hosseini MS, Jafari L, Shiri Heris R, Gharehbaghian A. Red blood cell alloimmunization in Iran: A Comprehensive review of the literature.Asian J Transfus Sci 2020;14:4-8


How to cite this URL:
Hosseini MS, Jafari L, Shiri Heris R, Gharehbaghian A. Red blood cell alloimmunization in Iran: A Comprehensive review of the literature. Asian J Transfus Sci [serial online] 2020 [cited 2020 Oct 1 ];14:4-8
Available from: http://www.ajts.org/article.asp?issn=0973-6247;year=2020;volume=14;issue=1;spage=4;epage=8;aulast=Hosseini;type=0