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  Indian J Med Microbiol
 

Figure 1: Schematic presentation of the infl uence of aprotonin on fibrinolysis and the kallikrein-kinin pathway. Aprotonin is known as an inhibitor for plasmin (at concentrations of >50 KIU/mL) and kallikrein (at concentrations of > 200 KIU/mL). Plasmin inhibition leads to a reduction of fi brinolysis. Inhibition of the kallikreinkinin pathway leads to a reduction of bradykinin formation, which may explain the improved hemodynamic stability after graft reperfusion, but it also decreases the formation of t-PA.

Figure 1: Schematic presentation of the infl uence of aprotonin on fibrinolysis and the kallikrein-kinin pathway. Aprotonin is known as an inhibitor for plasmin (at concentrations of >50 KIU/mL) and kallikrein (at concentrations of > 200 KIU/mL). Plasmin inhibition leads to a reduction of fi brinolysis. Inhibition of the kallikreinkinin pathway leads to a reduction of bradykinin formation, which may explain the improved hemodynamic stability after graft reperfusion, but it also decreases the formation of t-PA.